Classes > 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide
Page last updated: 2024-08-05 13:39:03
2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide
A member of the class of indazoles that is 2H-indazole substituted by 4-(piperidin-3-yl)phenyl and aminocarbonyl groups at positions 2 and 7, respectively. It is a potent PARP1 inhibitor with IC50 of 3.2 nM.
ChEBI ID: 177298
Members (1)
| Member | Definition | Role |
|---|
| niraparib | A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. | niraparib |
Research
Studies (211)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (0.47) | 29.6817 |
| 2010's | 83 (39.34) | 24.3611 |
| 2020's | 127 (60.19) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|
| Trials | 46 (21.70%) | 5.53% |
| Reviews | 36 (16.98%) | 6.00% |
| Case Studies | 8 (3.77%) | 4.05% |
| Observational | 3 (1.42%) | 0.25% |
| Other | 119 (56.13%) | 84.16% |